Maria Branyas Morera lived an extraordinarily long life, passing away last year at the age of 117 years and 168 days. Born in the United States in 1907, she moved with her family to Catalonia in 1915 and remained there for the rest of her life. Over more than a century, she witnessed the rise and fall of eras — two world wars, the leadership of 21 U.S. presidents, and technological changes that reshaped daily existence in ways few could have imagined.
Her longevity inevitably drew global attention, not only for its rarity but for the quality of life she maintained well into old age. Unlike many supercentenarians, Maria remained relatively free of the chronic illnesses that often accompany advanced aging. Aware that her life might offer insight beyond her own story, she expressed a clear wish before her death: that doctors study her biology in hopes of helping others live longer, healthier lives.
Researchers from the University of Barcelona and the Josep Carreras Leukaemia Research Institute carried out an in-depth analysis, examining her DNA, blood markers, and cellular aging processes. The study was led by Manel Esteller, who described Maria as a rare case that challenged conventional assumptions about aging.According to Esteller, Maria appeared to defy the typical link between advanced age and disease. He explained that her case offered, for the first time, a clearer separation between “being old” and “being sick.” While her genetic makeup played a central role, researchers suggested that future therapies might one day replicate some of these protective effects through targeted treatments.
Biological findings were striking. Despite being 117, Maria’s biological age was estimated to be closer to 100–105. She had exceptionally low levels of harmful cholesterol and triglycerides, alongside unusually high levels of protective “good” cholesterol — a profile more commonly seen in much younger individuals.Lifestyle also mattered. Maria exercised regularly, avoided smoking and alcohol, and maintained a strong social life, staying mentally engaged and emotionally connected. Her daily routine included a cereal-based smoothie made with eight different grains, and she frequently consumed La Fageda yogurt, a probiotic-rich food she personally credited as part of her diet. Researchers noted that such probiotics may help reduce inflammation and support gut health.
One of the most intriguing findings involved her telomeres. While they were very short — typically a marker of aging — scientists believe this may have limited uncontrolled cell division, potentially reducing cancer risk.
