Your skin isn’t just the body’s largest organ — it can also serve as an early warning system for serious health problems. Doctors are increasingly turning to subtle skin changes to help diagnose underlying diseases before they become life-threatening. From discoloration and rashes to nail irregularities, the skin often reveals clues long before internal symptoms appear. Dermatologists report that certain skin signals can indicate heart disease, diabetes, autoimmune disorders, liver problems, or even cancer.